Rabbit Secondary Antibodies
ABclonal Technology pan 14-3-3 Rabbit mAb
This gene encodes a protein from the 14-3-3 family which mediates signal transduction by binding phosphoserine-containing proteins This highly conserved protein family is present in both plants and mammals with the human protein 99% identical to its mouse and rat counterparts It is upregulated in patients with amyotrophic lateral sclerosis The gene contains a 6 bp tandem repeat in its 5 UTR but no correlation with disease severity has been found The protein interacts with RAF1 and CDC25 phosphatases suggesting involvement in mitogenic signaling and cell cycle regulation Two transcript variants encoding the same protein have been identified
Cayman Chemical p27KIp1CTerm RabbIt Monc 100uL
A BET family protein inhibitor inhibits binding of BRD2 BRD3 and BRD4 to an acetylated histone H4 peptide in vitro decreases Myc levels in and inhibits proliferation of AML DLBCL and MM cells reduces tumor growth in AML DLBCL and MM mouse xenograft models reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
Cayman Chemical -ActIn-Term RabbIt Monc 50uL
An IKKB NBD mimetic inhibits the protein-protein interaction between NEMO/IKKY and IKKB inhibits TNF-a-induced NF-KB activation in a reporter assay from 25-150 UM reduces LPS-induced IL-6 production in RAW 264.7 cells improves grip strength in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg
ABclonal Technology FATP2/SLC27A2 Rabbit mAb
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family Although differing in substrate specificity subcellular localization and tissue distribution all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters and thereby play a key role in lipid biosynthesis and fatty acid degradation This isozyme activates long-chain branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives It is expressed primarily in liver and kidney and is present in both endoplasmic reticulum and peroxisomes but not in mitochondria Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Cayman Chemical ClusTRInCTRm RabbIt Mon 100uL
An ionizable cationic lipid (pKa 6 09) has been used in the generation of LNPs for the delivery of mRNA siRNA and plasmid DNA in vitro and in vivo LNPs containing ALC-0315 and encapsulating siRNA targeting Factor VII mRNA decrease Factor VII mRNA levels in hepatocytes in mice administration of SARS-CoV-2 mRNA in ALC-0315-containing LNPs induces the production of IgG that binds to the SARS-CoV-2 BD) in rhesus macaques with a boost in antigen-specific IgG GMTs seven and 14 days after a second dose LNPs containing ALC-0315 and encapsulating ovalbumin mRNA reduce tumor volume in an ovalbumin-expressing B16/F10 murine melanoma model
ABclonal Technology CD1d Rabbit mAb
Enables T cell receptor binding activity and endogenous lipid antigen binding activity Involved in NK T cell differentiation and regulation of immature T cell proliferation in thymus Acts upstream of or within several processes including antigen processing and presentation exogenous lipid antigen via MHC class Ib positive regulation of cytokine production and positive regulation of leukocyte activation Located in endosome external side of plasma membrane and lysosome Is expressed in forebrain intestine jaw bone and liver Human ortholog(s) of this gene implicated in pulmonary tuberculosis Orthologous to human CD1D (CD1d molecule)
ABclonal Technology ALPK1 Rabbit mAb
- Protein Kinase 1 also known as - ALPK1 is associated with chronic kidney disease (CKD) myocardial infarction gout and type 2 diabetes According to reports ALPK1 mutations can lead to serious deficits in motor coordination in mice ALPK1 can enhance the expression of pro-inflammatory cytokines including IL-1 in cultured human THP1 and human embryonic kidney 293 (HEK293) cells (PMID 31557402 PMID 26275947) IL-8 and TGF- 1 The ALPK1 short subtype (108 kDa) is highly expressed in the brain spinal cord heart lungs spleen thymus small intestine skin and testes while detecting skeletal muscle and kidney ALPK1 isoform (130 kDa) appears in the heart lungs thymus and skin As a novel innate immune receptor ALPK1 can recognize bacteria-derived small molecule ADP-heptose and activate the immune response (PubMed 30111836 PubMed 30111836)
Cayman Chemical ntIHIstag RabbIt MoncLNa 100ug
Immunogen: Mixture of a peptide with 6xHis-tag at the N-terminus and another peptide with 6xHis-tag at the C-terminus • Host: Rabbit • Species Reactivity: (+) All species • Cross Reactivity: (+) Recombinant proteins containing the 6xHis-tag, 10xHis-tag fused to either the amino or carboxy terminus; (-) Other endogenous protein in mammalian cells or bacteria • Application(s): WB, FC, ICC, IHC, and IP • A probe for immunochemical detection of His tags on recombinant proteins by FC, ICC, IHC, IP, or WB
Cell Signaling Technology PD-L1 D2H6O Rabbit mAb BSA and Azide Free 100 ug
PD-L1 D2H6O Rabbit mAb BSA and Azide Free 100 ug
ABclonal Technology ATP5G1 Rabbit mAb
This gene encodes a subunit of mitochondrial ATP synthase Mitochondrial ATP synthase catalyzes ATP synthesis utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation ATP synthase is composed of two linked multi-subunit complexes the soluble catalytic core F1 and the membrane-spanning component Fo comprising the proton channel The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha beta gamma delta and epsilon) assembled with a stoichiometry of 3 alpha 3 beta and a single representative of the other 3 The proton channel seems to have nine subunits (a b c d e f g F6 and 8) This gene is one of three genes that encode subunit c of the proton channel Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein Alternatively spliced transcript variants encoding the same protein have been identified
ABclonal Technology RPL11 Rabbit mAb
Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 60S subunit The protein belongs to the L5P family of ribosomal proteins It is located in the cytoplasm The protein probably associates with the 5S rRNA Alternatively spliced transcript variants encoding different isoforms have been found for this gene As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome
ABclonal Technology CYP24A1 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This mitochondrial protein initiates the degradation of 1 25-dihydroxyvitamin D3 the physiologically active form of vitamin D3 by hydroxylation of the side chain In regulating the level of vitamin D3 this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Cayman Chemical HIston H4CTerm RabbIt Mo 100ug
Immunogen: Peptide corresponding to the C-terminus of human histone H4 • Host: Rabbit • Species Reactivity: (+) Vertebrates • Cross Reactivity: (+) H4A independent of PTMs; (-) Other histone proteins • Applications: ELISA, ICC, multiplex-based assays, WB
ABclonal Technology KPNB1 Rabbit mAb
Nucleocytoplasmic transport which requires energy and signals occurs through nuclear pore complexes in the nuclear envelope Import of proteins with a nuclear localization signal (NLS) involves the NLS import receptor a heterodimer of importin alpha and beta subunits (karyopherins) Importin alpha binds the NLS cargo in the cytoplasm and importin beta docks the complex at the nuclear pore With nucleoside triphosphates and Ran GTPase the complex enters the pore dissociating into importin alpha and beta Importin alpha carries the cargo into the nucleoplasm while importin beta stays at the pore Importin beta interacts with FG repeats of nucleoporins to aid translocation This gene encodes a member of the importin beta family with two splice variants encoding different isoforms
ABclonal Technology RAB8A Rabbit mAb
This gene encodes a protein in the RAS superfamily a group of small GTP/GDP-binding proteins ( 200 amino acids) involved in intracellular signaling RAB/YPT family members including this protein may help transport proteins from the endoplasmic reticulum to the Golgi and plasma membrane The protein shares high sequence similarity with dog RAB8 (97%) and mouse MEL (96%) and contains the four conserved GTP/GDP-binding sites typical of RAS proteins It also has a C-terminal CAAX motif common in RAS proteins but absent in most RAB/YPT proteins Although originally identified as a transforming gene from a melanoma cell line no clear link between this gene (MEL) and malignant melanoma has been established It is located about 800 kb downstream of MY09B on chromosome 19p13 1